Associate Scientist III

Associate Scientist III, wanted by Insitro, Inc. in South San Francisco, CA. Onboarding new cell models and developing quality control metrics for automated high-throughput arrayed genetic and compounding cell-screening assays suitable for downstream machine learning based discovery; Preparing, optimizing, and implementing real-time qPCR assays to support comprehensive target validation screenings by measuring knockdown efficiency, generating dose-response curves, and screening compound inhibitors. Applying advanced perturbation techniques—such as RNA interference, CRISPR-based gene editing, and small molecule modulation—to ensure assay fidelity, confirm target engagement, and generate robust, precise data for evaluating gene silencing effectiveness and compound efficacy; Leveraging on-flight QC and advanced Python-based data analysis to systematically assess assay performance, ensuring data quality and reproducibility for high-throughput screening, and driving insights into new assay development. Independently troubleshoot and characterize assay performance issues, optimizing key parameters and informing critical decisions. Present findings and data-driven recommendations to cross-functional teams to facilitate strategic improvements in assay design and execution; Developing confocal imaging experiments that result in high-content imaging data and perform in-house image analyses for assay characterization; In time metadata registration and maintaining thorough documentation within electronic lab notebooks (ELNs), ensuring data traceability and compliance. Leading the development and continuous improvement of standard operating procedures (SOPs), while upholding all laboratory safety protocols and training standards to support operational excellence; Designing and developing innovative assay readout panels, incorporating advanced techniques and methodologies to enhance the sensitivity, accuracy, and scalability of screening assays. Ensuring the new panels meet the s