Pioneering Medicines: Senior Principal Scientist, In Vitro Pharmacology

About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship’s innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship’s bioplatform companies. Within Flagship’s Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners’ R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary: Pioneering Medicines is seeking an accomplished and highly collaborative Senior Principal Scientist, In Vitro Pharmacology to lead the development and implementation of innovative in vitro pharmacology strategies across a diverse portfolio of therapeutic programs. This role will serve as a scientific leader responsible for designing, developing, validating, and applying cell-based assays that enable lead identification, lead optimization, mechanism of action studies, and translational as well as in vivo decision-making. The successful candidate will work closely with multiple therapeutic areas spanning Immunology, Oncology, and Metabolic diseases, as well as Translational Sciences, and In Vivo Pharmacology teams to accelerate the discovery and development of transformative therapeutics. The ideal candidate is an innovative scientist with deep expertise in assay development, mechanistic pharmacology, and matrix leadership within a fast-paced, entrepreneurial research environment. Key Responsibilities: Scientific Leadership • Lead the design, development, optimization, qualification,