Principal Scientist, Pooled Functional Screening

Company Summary FL130 (Flagship Labs 130) is an early-stage biotechnology startup aiming to answer an ambitious and exciting question: What if… we could systematically identify bioactive peptides to inspire next-generation therapies and uncover novel targets? To answer this question, FL130 is pioneering a novel approach to peptide screening, and is recruiting a team of top-tier scientists to help build it. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative mindset with the resources and know-how of Flagship Pioneering. FL130 is backed by Flagship Pioneering, a company that invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since 2000, Flagship has originated and fostered the development of more than 100 scientific ventures advancing human health and sustainability, including Moderna, Generate Biomedicines, and Alltrna. Position Summary We are seeking a motivated and highly collaborative Principal Scientist to design, stand up and run high-throughput pooled screening campaigns. The successful candidate will have a strong track record designing large libraries for high-throughput screening as well as running pooled, FACS-based screens, from library production and transduction through selection, sequencing, and analysis (including culturing and screening in primary and primary-like cell lines). This role is among the first hires, affording the exciting opportunity to shape and influence the company’s scientific direction. This is a hands-on role with substantial ownership for a scientist who is excited to set technical direction from day one and, over time, help build the team. Key Responsibilities Plan, execute, and analyze high-throughput pooled screens using FACS as the primary selection modality, owning the full experimental cycle end to end. Design and build custom DNA and oligo libraries for high-throughput pooled s