Principal Scientist, Protein Production & Engineering

Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires. POSITION OVERVIEW : Disc Medicine is seeking a detailed-oriented and experienced protein biochemist who will join our Innovation team as a Principal Scientist/Associate Director reporting to our Senior Director, Protein production and engineering. This individual will lead the discovery, design, production and/or characterization of biologics at various discovery and development stages, effectively communicate project updates and contribute to the company portfolio with meaningful opportunities for professional development. RESPONSIBILITIES: Provide scientific leadership in the planning, execution, and data interpretation across multiple biologics discovery programs. Lead protein engineering strategies for various antigens and biologics (antibodies and multi-specifics) using experimental, computational and structural biology tools Design and oversee the protein production and detailed characterization processes to support projects across the Innovation portfolio Drive early-stage developability assessment workflows of biologics Support mechanisms of action studies through assay development Support the selection of lead molecules to advance pipeline programs. Critically evaluate scientific literature, synthesize novel hypoth