Scientist II, Arrayed Screening

THE OPPORTUNITY The unprecedented convergence of multi-modal data and AI has the potential to revolutionize drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our success depends on our ability to attract, develop, inspire, and retain amazing, diverse talent and build a collaborative, high-performing, inclusive, and equitable culture. insitro is seeking a highly motivated Scientist II, Arrayed Screening to join our experimental biology and screening organization. In this role, you will help build, optimize, and execute high-throughput arrayed screening workflows that generate high-quality, decision-grade biological datasets for drug discovery. This is a highly collaborative role at the interface of cell biology, assay development, automated screening, disease modeling, and machine learning. You will work closely with biologists, bioengineers, automation scientists, data scientists, machine learning scientists, and drug discovery teams to design and run scalable cell-based and biochemical assays across therapeutic programs. The ideal candidate brings deep hands-on experience in cell-based assay development, high-throughput screening, mammalian cell culture, and quantitative data analysis, and is excited to generate robust biological data that can power ML-driven drug discovery. This role reports to the Director, High Throughput Biology and requires you to be onsite at our South San Francisco office 5 days per week. RESPONSIBILITIES - Develop, optimize, and execute arrayed screening assays in 96- and 384-well plate formats, including endpoint, kinetic, imaging-based, and/or biochemical readouts. - Design and implement cell-based screening workflows using immortalized, primary, iPSC-derived, or engineered cellular models. - Support small-molecule, genetic, and/or perturbational screening efforts, including assay development, target validation, mechanism-of-action studies, and screening campaigns. - Partner wi