Senior Associate Scientist II

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com . Duties: Manage database and serve as primary liaison for mRNA requests across Prime’s research and program teams. Responsible for independently executing mRNA production at various scales; from high-throughput plate-based scale for screening using automation, to lab scale, to production of clinically-representative GLP toxicology batches, and serve as Person in Plant for GMP manufacturing to provide technical oversight. Contribute to both guide RNA production at various sites and scales (research, process scale and GMP) as needed. Collaborate with Analytical and QC teams to align testing and release workflows, ensuring efficient material readiness. Track and communicate batch status, material availability, and testing timelines to stakeholders. Execute critical experiments and batch runs to gen