Senior Electrical Engineer, PCB Systems

About Tilde (FL110) Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. Our goal is to create programmable biological measurement systems capable of extracting rich molecular information from single-molecule interactions. We believe nanopores generate a high-dimensional measurement of molecular identity and behavior that remains largely untapped. Unlocking that information requires new computational approaches — ones that don't yet exist — built by people who are comfortable working at the edge of what's known. At Tilde, you will work alongside scientists and engineers from diverse disciplines to help define how a new generation of biological sensing systems extract meaning from the physical world. Tilde is backed by Flagship Pioneering, which brings the long-term vision and resources needed to build platforms that don't fit neatly into existing categories. Position Summary We are seeking a highly motivated and experienced Senior Electrical Engineer with deep expertise in printed circuit board (PCB) design and development to join our multidisciplinary engineering team. This individual will play a critical role in the design, layout, integration, and validation of complex PCBs that support our next-generation proteomics platform. The ideal candidate will have strong experience in mixed-signal and high-speed PCB design, signal integrity, power integrity, and system-level integration. This role requires close collaboration with firmware, mechanical, bioengineering, and systems teams to deliver robust, manufacturable, and high-performance hardware solutions from concept through production. Key Responsibilities Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems. Architect mixed-signal, high-speed, and low-noise circuit designs including analog front ends,