Research Scientist I/II, Immunology

JOB SUMMARY We are seeking a highly motivated, hands-on Research Scientist I/II with strong immunology training to join the Biology group and support small-molecule drug discovery programs at Iambic Therapeutics. The successful candidate will design and execute in vitro and ex vivo studies that generate high-quality data for target validation, hit-to-lead, lead optimization, and development candidate selection. The candidate will collaborate closely with colleagues in biology, medicinal chemistry, DMPK, in vivo pharmacology, computational biology, machine learning, and compound management groups. This role is based at our San Diego headquarters. KEY RESPONSIBILITIES - Design, develop, optimize, troubleshoot, and execute assays using disease-relevant immune cells and tissues, including primary human and/or pre-clinical immune cells, whole blood, cell lines, and tissue-derived systems, to measure potency, selectivity, target engagement, mechanism of action, and functional immune responses. - Run recurring compound-profiling assays and generate timely, reproducible data to support medicinal chemistry design-make-test-analyze cycles from hit-to-lead through lead optimization and development candidate selection. - Apply quantitative pharmacology and rigorous data-quality practices to analyze concentration-response relationships, assay performance, reproducibility, and biological relevance. - Maintain accurate electronic laboratory records, protocols, and data packages; communicate results, technical risks, and recommended next experiments at biology and project-team meetings. - Support in vivo immunology studies by contributing to experimental plans and readout selection, processing study samples, conducting ex vivo analyses, and interpreting exposure, PK/PD, biomarker, and efficacy data with in vivo pharmacology and DMPK colleagues. - Support assay transfer and external studies with CROs or collaborators by executing internal bridging work, reviewing protocols and data,